From Plant to Patient: Thapsigargin, a Tool for Understanding Natural Product Chemistry, Total Syntheses, Biosynthesis, Taxonomy, ATPases, Cell Death, and Drug Development | SpringerLink
MANF Ablation Causes Prolonged Activation of the UPR without Neurodegeneration in the Mouse Midbrain Dopamine System | eNeuro
The SERCA pump as a therapeutic target: Making a “smart bomb” for prostate cancer
Frontiers | The Cross-Links of Endoplasmic Reticulum Stress, Autophagy, and Neurodegeneration in Parkinson's Disease
Chemical Specifications
Promising therapeutic effect of thapsigargin nanoparticles on chronic kidney disease through the activation of Nrf2 and FoxO1 - Figure f8 | Aging
Thapsigargin: key to new host-directed coronavirus antivirals?: Trends in Pharmacological Sciences
Autophagic degradation of stromal interaction molecule 2 mediates disruption of neuronal dendrites by endoplasmic reticulum stress - Zhou - 2019 - Journal of Neurochemistry - Wiley Online Library
Peptide–drug conjugate-based novel molecular drug delivery system in cancer: Trends in Pharmacological Sciences
Coupling endoplasmic reticulum stress to the cell death program | Cell Death & Differentiation
Cell death induced by the ER stressor thapsigargin involves death receptor 5, a non-autophagic function of MAP1LC3B, and distinct contributions from unfolded protein response components | Cell Communication and Signaling | Full Text
Graphical Abstract
Frontiers | Mechanism of Endoplasmic Reticulum Stress in Cerebral Ischemia
ER-phagy: mechanisms, regulation, and diseases connected to the lysosomal clearance of the endoplasmic reticulum | Physiological Reviews
Revealing Protein Aggregates under Thapsigargin-Induced ER Stress Using an ER-Targeted Thioflavin | ACS Sensors
Sestrin2 suppression aggravates oxidative stress and apoptosis in endothelial cells subjected to pharmacologically induced endoplasmic reticulum stress - ScienceDirect
NAADP/SERCA3-Dependent Ca2+ Stores Pathway Specifically Controls Early Autocrine ADP Secretion Potentiating Platelet Activation | Circulation Research
Thapsigargin sensitizes human esophageal cancer to TRAIL-induced apoptosis via AMPK activation | Scientific Reports
Effect of endoplasmic reticulum calcium on paraquat‑induced apoptosis of human lung type II alveolar epithelial A549 cells
Pancreatic INS-1 β-Cell Response to Thapsigargin and Rotenone: A Comparative Proteomics Analysis Uncovers Key Pathways of β-Cell Dysfunction | Chemical Research in Toxicology
Tunicamycin specifically aggravates ER stress and overcomes chemoresistance in multidrug-resistant gastric cancer cells by inhibiting N-glycosylation | Journal of Experimental & Clinical Cancer Research | Full Text
Current understanding of imeglimin action on pancreatic β‐cells: Involvement of mitochondria and endoplasmic reticulum homeostasis - Fauzi - 2023 - Journal of Diabetes Investigation - Wiley Online Library
Cancer metabolism and mitochondria: Finding novel mechanisms to fight tumours - eBioMedicine
Ca2+ release or Ca2+ entry, that is the question: what governs Ca2+ oscillations in pancreatic β cells? | American Journal of Physiology-Endocrinology and Metabolism
Differential impact of imipramine on thapsigargin- and tunicamycin-induced endoplasmic reticulum stress and mitochondrial dysfunction in neuroblastoma SH-SY5Y cells - ScienceDirect
